Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Imperatoxin A TFA | 98.7% | 3758.35 (free base) | 1 MG
Imperatoxin A TFA is a peptide toxin derived from the venom of the African scorpion Pandinus imperator. It acts as a Ca2+-release channels/ryanodine receptors (RyRs) activator, enhancing the influx of Ca2+ from the sarcoplasmic reticulum into the cell.
- Purity of 98.65%
- Molecular weight of 3758.35 (free base)
- Appearance as a white to off-white solid
- Soluble in H2O at ≥ 100 mg/mL
Medchemexpress LLC G-Pen-GRGDSPCA (TFA) | 98.8% | 948.04 | 5 MG
G-Pen-GRGDSPCA (TFA) is a solid, white to off-white chemical product primarily identified for use as a laboratory chemical and in the manufacture of substances. It demonstrates stability under recommended storage conditions.
- Appearance: white to off-white solid
- Chemical stability: stable under recommended storage conditions
- Identified uses: laboratory chemicals, manufacture of substances
- Purity: 98.76% (LCMS)
- Consistent with structure (LCMS)
Medchemexpress LLC Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Gastric inhibitory peptide (GIP), human (TFA) | 98.5% | 4983.53 | 5 MG
Medchemexpress LLC Dendrotoxin-I TFA | 99.9% | 7149.24 | 500 UG
Dendrotoxin-I TFA is a potent K+ channel blocker effective against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6, with IC50s ranging from 0.13-50 nM. This neurotoxin holds potential in cancer research, as demonstrated by its significant tumor growth inhibition effect when combined with hyperthermia in nude mice with MCF-7 cells.
- Potent K+ channel blocker
- Effective against voltage-gated potassium channel subunits KV1.1, KV1.2, and KV1.6
- Exhibits neurotoxic properties
- Potential for use in cancer research
- Demonstrated tumor growth inhibition in in vivo studies
Medchemexpress LLC L-Phenylalaninamide, 4-(methylsulfonyl)-L-2-aminobutanoyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-D-lysyl-N-(8-aminooctyl)- (TFA) | 99.0% | 996.23 (free base) | 25 MG
Ebiratide (HOE-427) TFA is an ACTH 4-9 derivative that acts directly on the central nervous system and exhibits memory-enhancing efficacy. It enhances acetycholine (ACh) metabolism in rat brain.
- ACTH 4-9 derivative
- Acts directly on the central nervous system
- Exhibits memory-enhancing efficacy
- Enhances acetylcholine (ACh) metabolism in rat brain
- Exhibits neuroprotective efficacy in electroconvulsive shock
- Exhibits anti-amnestic efficacy in Scopolamine (HY-N0296)-induced memory impairment in mice model
Medchemexpress LLC MtvkPabc-p5 TFA | 1190.22 | C54H74F3N11O16 | 5 MG
MTvkPABC-P5 TFA is a Toll-like receptor 7 (TLR7) agonist and immune stimulant used as a reagent for synthesizing immune-stimulating antibody conjugates (ISACs). It is supplied as the trifluoroacetic acid (TFA) salt in solid form. Molecular formula: C54H74F3N11O16; molecular weight: 1190.22.
- Acts as a TLR7 agonist and immune stimulant.
- Used to synthesize immune-stimulating antibody conjugates (ISACs).
- Supplied as the trifluoroacetic acid (TFA) salt in solid form.
- Storage: solid -20°C; protect from light; store under nitrogen.
- Available pack sizes: 1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg.
Medchemexpress LLC KS-133 (TFA) | 98.95% | 1672.93 | 1 MG
KS-133 TFA is a highly selective and potent antagonist of the vascular active enteropeptide receptor 2 (VIPR2). It reverses the tumor-promoting M2 phenotype of tumor-associated macrophages to the anti-tumor M1 phenotype, alters the tumor immune microenvironment, and inhibits tumor growth. It is suitable for research on schizophrenia and cancer immune regulation.
- Highly selective and potent VIPR2 antagonist
- IC50 values for Ca influx measurement: 24.8 nM; cAMP measurement: 500 nM
- Reverses M2 to M1 macrophage phenotype
- Alters tumor immune microenvironment and inhibits tumor growth
- Inhibits excessive VIPR2 activation, preventing cognitive impairments and neuronal damage
- Demonstrates anti-tumor activity and synergistic effects with anti-PD-1 antibodies
Medchemexpress LLC Saralasin TFA | 34273-10-4 | 99.18% | 1026.07 | 25 MG
Saralasin TFA, an octapeptide analog of angiotensin II, functions as a competitive angiotensin II receptor antagonist and exhibits partial agonist activity. It is utilized in the research of renovascular hypertension and renin-dependent (angiotensinogenic) hypertension.
- Competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM.
- Exhibits partial agonist activity.
- Inhibits cell growth in 3T3 and SV3T3 cells.
- Restores potassium currents in myocytes.
- Inhibits binding of FITC-Ang II to rat liver membrane preparation.
- Reduces ovulation rate and prostaglandin levels in vitro.
- Ameliorates oxidative stress and tissue injury in cerulein-induced pancreatitis in rats.
- Increases serum renin activity in normal, conscious rats.
Medchemexpress LLC QL47B TFA | 96.0% | 992.07 | 5 MG
QL47B TFA is a biotinylated analogue of QL47 (HY-80003), functioning as a potent inhibitor of BTK with an IC50 value of 1.3 μM. It also exhibits anti-tumor activity.
- Potent inhibitor of BTK (IC50 value of 1.3 μM).
- Exhibits anti-tumor activity.
Medchemexpress LLC SsK36 TFA | 99.3% | 1771.04 (free base) | 5 MG
ssK36 TFA is a supersubstrate peptide of the histone methyltransferase (SET) domain protein 2 (SETD2). It is designed for the SETD2 protein, a specific PKMT, responsible in human cells for adding methyl groups to the 36th lysine residue of histone H3 (H3K36) to form H3K36me3. This peptide can be methylated by SETD2 at a rate more than 100 times faster than the natural substrate H3K36 and can be used to study the catalytic mechanism of PKMTs, especially substrate specificity and catalytic efficiency.
- Purity of 99.34%
- Molecular weight of 1771.04 (free base)
- Formula: C79H127N29O18.xC2HF3O2
- Appearance: Solid
- Color: White to off-white
- Sequence: Ala-Pro-Arg-Phe-Gly-Gly-Val-Lys-Arg-Pro-Asn-Arg-Tyr-Arg-Pro
- Sequence shortening: APRFGGVKRPNRYRP
- Solubility (in vitro): 1 mg/mL in H2O (requires ultrasonic)
Medchemexpress LLC PBA-1105 TFA | 99.6% | 754.83 | 5 MG
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. It selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. This compound increases the autophagic flux of Ub-conjugated aggregates and induces autophagic degradation of misfolded proteins and aggregates at nanomolar concentrations. It is for research use only.
- Induces p62 self-oligomerization.
- Selectively binds to exposed hydrophobic regions of misfolded proteins.
- Facilitates degradation via the autophagic pathway.
- Increases the autophagic flux of Ub-conjugated aggregates.
- Induces autophagic degradation of mutant tau and misfolded proteins.
Medchemexpress LLC Spantide I (TFA) | 99.32% | 5 MG
Spantide I TFA is a substance P analog and a selective NK1 receptor antagonist. It has Ki values of 230 nM for NK1 and 8150 nM for NK2 receptors. This compound can reduce type 1 cytokines and enhance type 2 cytokine IL-10 in infected corneas, which leads to a significant reduction in corneal perforation. It is for research use only, not for sale to patients.
- Substance P analog
- Selective NK1 receptor antagonist
- Reduces type 1 cytokines
- Enhances type 2 cytokine IL-10
- Reduces corneal perforation